Precision Targeting of IL-6 Trans-Signaling: Restoring Balance Between Inflammation & Regeneration
- Present quantitative modeling insights predicting that selective trans-signaling inhibition will permit faster tissue healing than global IL-6 blockade
- Discuss translational strategies to validate these findings through biomarkers, imaging modalities, and early proof-of-concept trials
- Highlight implications for trial design, including precision endpoints, patient stratification, and integrating modeling into clinical decision making